Work Package 1 – in vitro exposure to PFOA
Sub-activity 1.1. Analysis of the effects of the in vitro exposure of ECs to PFOA
Sub-activity 1.2. Analysis of the effects of the in vitro exposure of GCs to PFOA
Sub-activity 1.3. Analysis of the effects of the in vitro exposure of HCs to PFOA
Sub-activity 1.4. BMDL modeling
Work Package 2 – in vivo exposure to PFOA
Sub-activity 2.1. Analysis of the effects of the sub-acute (28 days) in vivo exposure of mice to PFOA
Sub-activity 2.2. Analysis of the effects of the sub-chronic (90 days) in vivo exposure of mice to PFOA
Sub-activity 2.3. BMDL modeling
Work Package 3 – PBTK modeling
Sub-activity 3.1. In vitro/In silico PFOA characterization
Sub-activity 3.2. Development of the human PBTK models
Sub-activity 3.3. PBTK modeling based on the human biomonitoring data
Sub-activity 3.4. PBTK modeling based on the in vitro data
Sub-activity 3.5. PBTK modeling based on the in vivo data
Sub-activity 3.6. BER and BCR calculation and comparison of different risk assessment approaches
Sub-activity 3.7. PSA and VGT
Work Package 4 – Dissemination
Sub-activity 4.1. Dissemination Plan
Sub-activity 4.2. Web-platform and social networks
Sub-activity 4.3. Conferences and publications
Sub-activity 4.4. Public engagement
Work Package 5 – Project management
Sub-activity 5.1. Administrative and financial coordination
Sub-activity 5.2. Data Management Plan
Sub-activity 5.3. Internal project meetings