About us


The Laboratory for Endocrine Disruptors and Signaling (ENDOS) is located at the Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad. Its research focus is mechanism of action of chemicals known as endocrine disruptors (ED), which are routinely found in our environment and which are known to interfere with hormone homeostasis. The emphasis is on detecting affected cellular signaling pathways, but also on detecting affected cellular events, gene expression and epigenetics.

The laboratory is equipped for molecular biology research, fluorimetric and spectrophotometric assays, histology, contains up-to date cell culture room, small zebrafish facility and rat facility

Main research areas include:

Impact of ED on reproduction. Impact on reproduction is being assessed by investigating mechanism of ED action in human and rat ovarian steroidogenic granulosa cells and in human spermatozoa. Both signaling and different reproductive parameters are evaluated.

Impact of ED on development. Impact on development is studied by exposing zebrafish embryos (Danio rerio) to ED and evaluating effects both while in embryonic stage and in adulthood, with the emphasis on gene expression, epigenetics and histology.

Impact of ED on other biological systems. Impact on different other biological systems is being assessed by using various cell lines, both in chronic and acute experimental set ups. Signaling and different cellular events are evaluated.